Drug interactions
Amphotericin b deoxycholate + Captopril-hydrochlorothiazide
Severity: Moderate
Amphotericin b deoxycholate and Captopril-hydrochlorothiazide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Amphotericin B deoxycholate causes renal potassium and magnesium wasting and nephrotoxicity. With hydrochlorothiazide, hypokalemia and hypomagnesemia are more likely, and with captopril, renal function may deteriorate further.
What this interaction means in plain words
Amphotericin b deoxycholate and Captopril-hydrochlorothiazide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive renal electrolyte wasting from the thiazide and amphotericin tubular toxicity, with ACE inhibition reducing glomerular filtration pressure in volume-depleted patients.
What to do
Monitor potassium, magnesium, and creatinine regularly during therapy and supplement electrolytes as needed. Consider holding the diuretic if volume depletion or renal impairment develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Captopril-hydrochlorothiazide
- Aliskiren + Captopril-hydrochlorothiazide Contraindicated
- Captopril-hydrochlorothiazide + Dofetilide Contraindicated
- Captopril-hydrochlorothiazide + Sacubitril / valsartan Contraindicated
- Aceclofenac + Captopril-hydrochlorothiazide Major
- Aldesleukin + Captopril-hydrochlorothiazide Major
- Amifostine + Captopril-hydrochlorothiazide Major
Frequently asked questions
Can I take Amphotericin b deoxycholate with Captopril-hydrochlorothiazide?
MediHelp rates the interaction as moderate. Amphotericin b deoxycholate and Captopril-hydrochlorothiazide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Amphotericin B deoxycholate causes renal potassium and magnesium wasting and nephrotoxicity. With hydrochlorothiazide, hypokalemia and hypomagnesemia are more likely, and with captopril, renal function may deteriorate further.
How serious is the interaction between Amphotericin b deoxycholate and Captopril-hydrochlorothiazide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor potassium, magnesium, and creatinine regularly during therapy and supplement electrolytes as needed. Consider holding the diuretic if volume depletion or renal impairment develops.
What other medicines interact with Captopril-hydrochlorothiazide?
MediHelp also lists interactions of Captopril-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Sacubitril / valsartan. The full list is on the Captopril-hydrochlorothiazide page.
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