Drug interactions
Amphotericin b deoxycholate + Vancomycin
Severity: Moderate
Amphotericin b deoxycholate and Vancomycin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both agents are nephrotoxic, and using them together can increase the risk of acute kidney injury. Renal impairment would also raise vancomycin exposure and the risk of further toxicity.
What this interaction means in plain words
Amphotericin b deoxycholate and Vancomycin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive nephrotoxicity through different direct renal tubular injury mechanisms.
What to do
Monitor serum creatinine and vancomycin trough or AUC levels frequently, keep patients well hydrated, and adjust the vancomycin dose to renal function. Use a less nephrotoxic antifungal when possible.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Amphotericin b deoxycholate and Vancomycin, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Vancomycin
- Amikacin + Vancomycin Major
- Bacitracin + Vancomycin Major
- Capreomycin + Vancomycin Major
- Cephaloridine + Vancomycin Major
- Cidofovir + Vancomycin Major
- Cisplatin + Vancomycin Major
Frequently asked questions
Can I take Amphotericin b deoxycholate with Vancomycin?
MediHelp rates the interaction as moderate. Amphotericin b deoxycholate and Vancomycin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both agents are nephrotoxic, and using them together can increase the risk of acute kidney injury. Renal impairment would also raise vancomycin exposure and the risk of further toxicity.
How serious is the interaction between Amphotericin b deoxycholate and Vancomycin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum creatinine and vancomycin trough or AUC levels frequently, keep patients well hydrated, and adjust the vancomycin dose to renal function. Use a less nephrotoxic antifungal when possible.
What other medicines interact with Vancomycin?
MediHelp also lists interactions of Vancomycin with, for example, Amikacin, Bacitracin, Capreomycin. The full list is on the Vancomycin page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
