Drug interactions
Amphotericin b deoxycholate + Vecuronium
Severity: Moderate
Amphotericin b deoxycholate and Vecuronium: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Amphotericin B deoxycholate can cause hypokalemia and hypomagnesemia, which can enhance and prolong the effect of vecuronium. This may delay recovery of muscle strength.
What this interaction means in plain words
Amphotericin b deoxycholate and Vecuronium can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Electrolyte disturbances (low potassium and magnesium) from amphotericin B-induced renal wasting potentiate non-depolarizing blockade.
What to do
Check and correct potassium and magnesium before and during anesthesia. Monitor with train-of-four and titrate vecuronium to effect.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Amphotericin b deoxycholate and Vecuronium, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Vecuronium
Frequently asked questions
Can I take Amphotericin b deoxycholate with Vecuronium?
MediHelp rates the interaction as moderate. Amphotericin b deoxycholate and Vecuronium can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Amphotericin B deoxycholate can cause hypokalemia and hypomagnesemia, which can enhance and prolong the effect of vecuronium. This may delay recovery of muscle strength.
How serious is the interaction between Amphotericin b deoxycholate and Vecuronium?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check and correct potassium and magnesium before and during anesthesia. Monitor with train-of-four and titrate vecuronium to effect.
What other medicines interact with Vecuronium?
MediHelp also lists interactions of Vecuronium with, for example, Amikacin, Bacitracin-neomycin-polymyxin, Capreomycin. The full list is on the Vecuronium page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
