Drug interactions
Capreomycin + Vecuronium
Severity: Major
Capreomycin and Vecuronium: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Capreomycin has neuromuscular blocking activity and can intensify and prolong vecuronium blockade. This can cause prolonged paralysis and respiratory insufficiency, especially with renal impairment.
What this interaction means in plain words
Capreomycin and Vecuronium can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Additive neuromuscular blockade through intrinsic curare-like effects of capreomycin at the neuromuscular junction.
What to do
Avoid combining when alternatives exist; otherwise reduce vecuronium dose and monitor with train-of-four until full recovery. Have ventilatory support ready and consider renal function.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Capreomycin and Vecuronium, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Vecuronium
Frequently asked questions
Can I take Capreomycin with Vecuronium?
MediHelp rates the interaction as major. Capreomycin and Vecuronium can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Capreomycin has neuromuscular blocking activity and can intensify and prolong vecuronium blockade. This can cause prolonged paralysis and respiratory insufficiency, especially with renal impairment.
How serious is the interaction between Capreomycin and Vecuronium?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid combining when alternatives exist; otherwise reduce vecuronium dose and monitor with train-of-four until full recovery. Have ventilatory support ready and consider renal function.
What other medicines interact with Vecuronium?
MediHelp also lists interactions of Vecuronium with, for example, Amikacin, Bacitracin-neomycin-polymyxin, Clindamycin. The full list is on the Vecuronium page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
