Drug interactions
Amphotericin b deoxycholate + Zidovudine
Severity: Moderate
Amphotericin b deoxycholate and Zidovudine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both agents can cause bone marrow suppression, and amphotericin B deoxycholate is also nephrotoxic. Combined use may worsen anemia and neutropenia and renal function.
What this interaction means in plain words
Amphotericin b deoxycholate and Zidovudine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive hematologic toxicity, with amphotericin-related nephrotoxicity that may reduce zidovudine glucuronide clearance.
What to do
Monitor complete blood counts and serum creatinine regularly, and reduce zidovudine dose or change therapy if cytopenias develop.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Zidovudine
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Zidovudine Contraindicated
- Stavudine + Zidovudine Contraindicated
- Atidarsagene autotemcel + Zidovudine Major
- Betibeglogene autotemcel + Zidovudine Major
- Carboplatin + Zidovudine Major
- Cisplatin + Zidovudine Major
Frequently asked questions
Can I take Amphotericin b deoxycholate with Zidovudine?
MediHelp rates the interaction as moderate. Amphotericin b deoxycholate and Zidovudine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both agents can cause bone marrow suppression, and amphotericin B deoxycholate is also nephrotoxic. Combined use may worsen anemia and neutropenia and renal function.
How serious is the interaction between Amphotericin b deoxycholate and Zidovudine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor complete blood counts and serum creatinine regularly, and reduce zidovudine dose or change therapy if cytopenias develop.
What other medicines interact with Zidovudine?
MediHelp also lists interactions of Zidovudine with, for example, Elvitegravir / cobicistat / emtricitabine / tenofovir df, Stavudine, Atidarsagene autotemcel. The full list is on the Zidovudine page.
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