Drug interactions
Amphotericin b phospholipid complex + Benazepril
Severity: Moderate
Amphotericin b phospholipid complex and Benazepril: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Amphotericin B lipid complex is nephrotoxic, though less than the deoxycholate form. Together with benazepril, renal function may decline, particularly with volume depletion.
What this interaction means in plain words
Amphotericin b phospholipid complex and Benazepril can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Amphotericin-induced renal vasoconstriction and tubular injury combined with ACE inhibitor loss of efferent arteriolar tone can reduce glomerular filtration.
What to do
Monitor serum creatinine and electrolytes regularly during treatment. Consider holding benazepril if renal function worsens.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Benazepril
- Aliskiren + Benazepril Contraindicated
- Benazepril + Sacubitril / valsartan Contraindicated
- Benazepril + Sacubitril-valsartan Contraindicated
- Amifostine + Benazepril Major
- Amiloride + Benazepril Major
- Amlodipine-hydrochlorothiazide-valsartan + Benazepril Major
Frequently asked questions
Can I take Amphotericin b phospholipid complex with Benazepril?
MediHelp rates the interaction as moderate. Amphotericin b phospholipid complex and Benazepril can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Amphotericin B lipid complex is nephrotoxic, though less than the deoxycholate form. Together with benazepril, renal function may decline, particularly with volume depletion.
How serious is the interaction between Amphotericin b phospholipid complex and Benazepril?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum creatinine and electrolytes regularly during treatment. Consider holding benazepril if renal function worsens.
What other medicines interact with Benazepril?
MediHelp also lists interactions of Benazepril with, for example, Aliskiren, Sacubitril / valsartan, Sacubitril-valsartan. The full list is on the Benazepril page.
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