Drug interactions
Ampicillin + Aspirin / citric acid / sodium bicarbonate
Severity: Minor
Ampicillin and Aspirin / citric acid / sodium bicarbonate: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
The aspirin in this effervescent product may slightly raise ampicillin levels through reduced renal secretion and protein binding displacement. The effect is small and rarely significant.
What this interaction means in plain words
Ampicillin and Aspirin / citric acid / sodium bicarbonate have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Salicylate competition for protein binding and renal tubular secretion.
What to do
No dose change is generally needed; watch for penicillin adverse effects with frequent high-dose use.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Ampicillin
- Allopurinol + Ampicillin Moderate
- Ampicillin + Bcg vaccine live Moderate
- Ampicillin + Chloramphenicol Moderate
- Ampicillin + Chloroquine Moderate
- Ampicillin + Cholera vaccine Moderate
- Ampicillin + Demeclocycline Moderate
Frequently asked questions
Can I take Ampicillin with Aspirin / citric acid / sodium bicarbonate?
MediHelp rates the interaction as minor. Ampicillin and Aspirin / citric acid / sodium bicarbonate have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. The aspirin in this effervescent product may slightly raise ampicillin levels through reduced renal secretion and protein binding displacement. The effect is small and rarely significant.
How serious is the interaction between Ampicillin and Aspirin / citric acid / sodium bicarbonate?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is generally needed; watch for penicillin adverse effects with frequent high-dose use.
What other medicines interact with Ampicillin?
MediHelp also lists interactions of Ampicillin with, for example, Allopurinol, Bcg vaccine live, Chloramphenicol. The full list is on the Ampicillin page.
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