Drug interactions
Ampicillin + Cholera vaccine
Severity: Moderate
Ampicillin and Cholera vaccine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
The oral live attenuated cholera vaccine contains a live bacterial strain that systemic antibiotics may reduce or kill. This may blunt the immune response to the vaccine.
What this interaction means in plain words
Ampicillin and Cholera vaccine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Antibacterial activity against the live attenuated vaccine strain reduces replication and immunogenicity.
What to do
Do not give the vaccine within 14 days after oral or parenteral antibiotics, per labeling. Postpone vaccination until the antibiotic course is complete.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ampicillin
- Allopurinol + Ampicillin Moderate
- Ampicillin + Bcg vaccine live Moderate
- Ampicillin + Chloramphenicol Moderate
- Ampicillin + Chloroquine Moderate
- Ampicillin + Demeclocycline Moderate
- Ampicillin + Eravacycline Moderate
Frequently asked questions
Can I take Ampicillin with Cholera vaccine?
MediHelp rates the interaction as moderate. Ampicillin and Cholera vaccine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. The oral live attenuated cholera vaccine contains a live bacterial strain that systemic antibiotics may reduce or kill. This may blunt the immune response to the vaccine.
How serious is the interaction between Ampicillin and Cholera vaccine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not give the vaccine within 14 days after oral or parenteral antibiotics, per labeling. Postpone vaccination until the antibiotic course is complete.
What other medicines interact with Ampicillin?
MediHelp also lists interactions of Ampicillin with, for example, Allopurinol, Bcg vaccine live, Chloramphenicol. The full list is on the Ampicillin page.
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