Drug interactions
Ampicillin + Demeclocycline
Severity: Moderate
Ampicillin and Demeclocycline: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Bacteriostatic tetracyclines can reduce the killing effect of penicillins on bacteria that need active growth. Evidence is mostly in vitro and from older clinical reports, but it may matter in serious infections such as meningitis.
What this interaction means in plain words
Ampicillin and Demeclocycline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Tetracycline-induced inhibition of bacterial growth reduces the activity of cell-wall-active beta-lactams.
What to do
Avoid combining in serious infections that need bactericidal therapy. If unavoidable, monitor clinical response closely.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ampicillin
- Allopurinol + Ampicillin Moderate
- Ampicillin + Bcg vaccine live Moderate
- Ampicillin + Chloramphenicol Moderate
- Ampicillin + Chloroquine Moderate
- Ampicillin + Cholera vaccine Moderate
- Ampicillin + Eravacycline Moderate
Frequently asked questions
Can I take Ampicillin with Demeclocycline?
MediHelp rates the interaction as moderate. Ampicillin and Demeclocycline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Bacteriostatic tetracyclines can reduce the killing effect of penicillins on bacteria that need active growth. Evidence is mostly in vitro and from older clinical reports, but it may matter in serious infections such as meningitis.
How serious is the interaction between Ampicillin and Demeclocycline?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid combining in serious infections that need bactericidal therapy. If unavoidable, monitor clinical response closely.
What other medicines interact with Ampicillin?
MediHelp also lists interactions of Ampicillin with, for example, Allopurinol, Bcg vaccine live, Chloramphenicol. The full list is on the Ampicillin page.
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