Drug interactions
Ampicillin + Aspirin
Severity: Minor
Ampicillin and Aspirin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Aspirin may displace ampicillin from protein binding and slow its renal secretion, slightly raising penicillin levels. The effect is generally modest and clinically minor.
What this interaction means in plain words
Ampicillin and Aspirin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Competition for plasma protein binding and renal tubular secretion by salicylate.
What to do
No dose adjustment is usually needed; monitor for penicillin adverse effects with high-dose aspirin.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Ampicillin
- Allopurinol + Ampicillin Moderate
- Ampicillin + Bcg vaccine live Moderate
- Ampicillin + Chloramphenicol Moderate
- Ampicillin + Chloroquine Moderate
- Ampicillin + Cholera vaccine Moderate
- Ampicillin + Demeclocycline Moderate
Frequently asked questions
Can I take Ampicillin with Aspirin?
MediHelp rates the interaction as minor. Ampicillin and Aspirin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Aspirin may displace ampicillin from protein binding and slow its renal secretion, slightly raising penicillin levels. The effect is generally modest and clinically minor.
How serious is the interaction between Ampicillin and Aspirin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment is usually needed; monitor for penicillin adverse effects with high-dose aspirin.
What other medicines interact with Ampicillin?
MediHelp also lists interactions of Ampicillin with, for example, Allopurinol, Bcg vaccine live, Chloramphenicol. The full list is on the Ampicillin page.
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