Drug interactions
Ampicillin + Atenolol-chlorthalidone
Severity: Minor
Ampicillin and Atenolol-chlorthalidone: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Oral ampicillin has been reported to lower atenolol absorption and blood levels in some studies. This may modestly reduce beta-blockade during antibiotic treatment. The effect is generally small and not often clinically relevant.
What this interaction means in plain words
Ampicillin and Atenolol-chlorthalidone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Ampicillin belongs to Anti Bacterial; Atenolol-chlorthalidone belongs to Cardiovascular.
Why it happens
Reduced gastrointestinal absorption of atenolol, mechanism not fully established.
What to do
No routine adjustment is needed; monitor heart rate and blood pressure during a course of oral ampicillin.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Ampicillin and Atenolol-chlorthalidone, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Atenolol-chlorthalidone
Other interactions of Ampicillin
- Allopurinol + Ampicillin Moderate
- Ampicillin + Bcg vaccine live Moderate
- Ampicillin + Chloramphenicol Moderate
- Ampicillin + Chloroquine Moderate
- Ampicillin + Cholera vaccine Moderate
- Ampicillin + Demeclocycline Moderate
Frequently asked questions
Can I take Ampicillin with Atenolol-chlorthalidone?
MediHelp rates the interaction as minor. Ampicillin and Atenolol-chlorthalidone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Oral ampicillin has been reported to lower atenolol absorption and blood levels in some studies. This may modestly reduce beta-blockade during antibiotic treatment. The effect is generally small and not often clinically relevant.
How serious is the interaction between Ampicillin and Atenolol-chlorthalidone?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine adjustment is needed; monitor heart rate and blood pressure during a course of oral ampicillin.
What other medicines interact with Atenolol-chlorthalidone?
MediHelp also lists interactions of Atenolol-chlorthalidone with, for example, Acebutolol, Aldesleukin, Amiodarone. The full list is on the Atenolol-chlorthalidone page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
