Drug interactions
Ampicillin + Eravacycline
Severity: Moderate
Ampicillin and Eravacycline: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Bacteriostatic tetracycline-class agents may blunt the bactericidal effect of penicillins, which depend on actively dividing bacteria. The clinical significance is uncertain, but it may matter in severe infections.
What this interaction means in plain words
Ampicillin and Eravacycline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ampicillin belongs to Anti Bacterial; Eravacycline belongs to Anti Bacterial.
Why it happens
Tetracycline-induced inhibition of bacterial protein synthesis and growth reduces the activity of cell-wall-active beta-lactams.
What to do
Avoid the combination in serious infections requiring bactericidal activity. If both are needed, monitor clinical response.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ampicillin
- Allopurinol + Ampicillin Moderate
- Ampicillin + Bcg vaccine live Moderate
- Ampicillin + Chloramphenicol Moderate
- Ampicillin + Chloroquine Moderate
- Ampicillin + Cholera vaccine Moderate
- Ampicillin + Demeclocycline Moderate
Other interactions of Eravacycline
- Amoxicillin-clavulanic acid + Eravacycline Moderate
- Amoxicillin + Eravacycline Moderate
- Ampicillin-sulbactam + Eravacycline Moderate
- Eravacycline + Warfarin Moderate
Frequently asked questions
Can I take Ampicillin with Eravacycline?
MediHelp rates the interaction as moderate. Ampicillin and Eravacycline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Bacteriostatic tetracycline-class agents may blunt the bactericidal effect of penicillins, which depend on actively dividing bacteria. The clinical significance is uncertain, but it may matter in severe infections.
How serious is the interaction between Ampicillin and Eravacycline?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination in serious infections requiring bactericidal activity. If both are needed, monitor clinical response.
What other medicines interact with Ampicillin?
MediHelp also lists interactions of Ampicillin with, for example, Allopurinol, Bcg vaccine live, Chloramphenicol. The full list is on the Ampicillin page.
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