Drug interactions
Ampicillin + Choline magnesium trisalicylate
Severity: Minor
Ampicillin and Choline magnesium trisalicylate: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Salicylates can reduce the renal tubular secretion of penicillins and may displace them from plasma proteins, which could modestly raise ampicillin exposure. The clinical effect is usually small, though higher-dose salicylate may add to bleeding risk because penicillins can affect platelet function.
What this interaction means in plain words
Ampicillin and Choline magnesium trisalicylate have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Competition for renal tubular organic anion secretion and plasma protein binding.
What to do
No dose change is generally needed; watch for bleeding or increased beta-lactam adverse effects when high-dose salicylate is used.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Ampicillin
- Allopurinol + Ampicillin Moderate
- Ampicillin + Bcg vaccine live Moderate
- Ampicillin + Chloramphenicol Moderate
- Ampicillin + Chloroquine Moderate
- Ampicillin + Cholera vaccine Moderate
- Ampicillin + Demeclocycline Moderate
Frequently asked questions
Can I take Ampicillin with Choline magnesium trisalicylate?
MediHelp rates the interaction as minor. Ampicillin and Choline magnesium trisalicylate have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Salicylates can reduce the renal tubular secretion of penicillins and may displace them from plasma proteins, which could modestly raise ampicillin exposure. The clinical effect is usually small, though higher-dose salicylate may add to bleeding risk because penicillins can affect platelet function.
How serious is the interaction between Ampicillin and Choline magnesium trisalicylate?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is generally needed; watch for bleeding or increased beta-lactam adverse effects when high-dose salicylate is used.
What other medicines interact with Ampicillin?
MediHelp also lists interactions of Ampicillin with, for example, Allopurinol, Bcg vaccine live, Chloramphenicol. The full list is on the Ampicillin page.
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