Drug interactions
Ampicillin + Lansoprazole
Severity: Minor
Ampicillin and Lansoprazole: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Oral ampicillin absorption may be modestly reduced when gastric pH is raised by a PPI. The effect is small and rarely alters outcomes of treatment.
What this interaction means in plain words
Ampicillin and Lansoprazole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Ampicillin belongs to Anti Bacterial; Lansoprazole belongs to Gastrointestinal Tract.
Why it happens
Elevated gastric pH may slightly reduce ampicillin absorption.
What to do
No routine adjustment is needed; reassess response if oral ampicillin is used for a serious infection.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Lansoprazole
- Lansoprazole + Mavacamten Contraindicated
- Lansoprazole + Rilpivirine Contraindicated
- Acalabrutinib + Lansoprazole Major
- Atazanavir + Lansoprazole Major
- Dacomitinib + Lansoprazole Major
- Dasatinib + Lansoprazole Major
Other interactions of Ampicillin
- Allopurinol + Ampicillin Moderate
- Ampicillin + Bcg vaccine live Moderate
- Ampicillin + Chloramphenicol Moderate
- Ampicillin + Chloroquine Moderate
- Ampicillin + Cholera vaccine Moderate
- Ampicillin + Demeclocycline Moderate
Frequently asked questions
Can I take Ampicillin with Lansoprazole?
MediHelp rates the interaction as minor. Ampicillin and Lansoprazole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Oral ampicillin absorption may be modestly reduced when gastric pH is raised by a PPI. The effect is small and rarely alters outcomes of treatment.
How serious is the interaction between Ampicillin and Lansoprazole?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine adjustment is needed; reassess response if oral ampicillin is used for a serious infection.
What other medicines interact with Lansoprazole?
MediHelp also lists interactions of Lansoprazole with, for example, Mavacamten, Rilpivirine, Acalabrutinib. The full list is on the Lansoprazole page.
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