Drug interactions
Ampicillin + Methyclothiazide
Severity: Minor
Ampicillin and Methyclothiazide: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Thiazide diuretics may modestly raise ampicillin exposure by competing for renal tubular secretion. The effect is small and rarely clinically relevant given the wide therapeutic index of ampicillin.
What this interaction means in plain words
Ampicillin and Methyclothiazide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Competition for renal tubular organic anion secretion reduces ampicillin clearance.
What to do
No action is usually needed. Consider dose review only in patients with significant renal impairment.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Ampicillin
- Allopurinol + Ampicillin Moderate
- Ampicillin + Bcg vaccine live Moderate
- Ampicillin + Chloramphenicol Moderate
- Ampicillin + Chloroquine Moderate
- Ampicillin + Cholera vaccine Moderate
- Ampicillin + Demeclocycline Moderate
Frequently asked questions
Can I take Ampicillin with Methyclothiazide?
MediHelp rates the interaction as minor. Ampicillin and Methyclothiazide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Thiazide diuretics may modestly raise ampicillin exposure by competing for renal tubular secretion. The effect is small and rarely clinically relevant given the wide therapeutic index of ampicillin.
How serious is the interaction between Ampicillin and Methyclothiazide?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No action is usually needed. Consider dose review only in patients with significant renal impairment.
What other medicines interact with Ampicillin?
MediHelp also lists interactions of Ampicillin with, for example, Allopurinol, Bcg vaccine live, Chloramphenicol. The full list is on the Ampicillin page.
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