Drug interactions
Ampicillin + Mycophenolate
Severity: Moderate
Ampicillin and Mycophenolate: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ampicillin can reduce mycophenolic acid exposure, and the resulting lower immunosuppression may raise the risk of rejection. The reduction is attributed to altered gut flora and less enterohepatic recycling, not to reduced renal clearance. The effect is usually modest and manageable.
What this interaction means in plain words
Ampicillin and Mycophenolate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Antibiotic-induced changes in gut flora reduce beta-glucuronidase deconjugation of mycophenolic acid glucuronide, impairing enterohepatic recirculation.
What to do
Monitor for signs of graft rejection or loss of immunosuppressive effect during and after the antibiotic course. Consider mycophenolic acid exposure monitoring in high-risk transplant patients.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ampicillin
- Allopurinol + Ampicillin Moderate
- Ampicillin + Bcg vaccine live Moderate
- Ampicillin + Chloramphenicol Moderate
- Ampicillin + Chloroquine Moderate
- Ampicillin + Cholera vaccine Moderate
- Ampicillin + Demeclocycline Moderate
Frequently asked questions
Can I take Ampicillin with Mycophenolate?
MediHelp rates the interaction as moderate. Ampicillin and Mycophenolate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ampicillin can reduce mycophenolic acid exposure, and the resulting lower immunosuppression may raise the risk of rejection. The reduction is attributed to altered gut flora and less enterohepatic recycling, not to reduced renal clearance. The effect is usually modest and manageable.
How serious is the interaction between Ampicillin and Mycophenolate?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for signs of graft rejection or loss of immunosuppressive effect during and after the antibiotic course. Consider mycophenolic acid exposure monitoring in high-risk transplant patients.
What other medicines interact with Ampicillin?
MediHelp also lists interactions of Ampicillin with, for example, Allopurinol, Bcg vaccine live, Chloramphenicol. The full list is on the Ampicillin page.
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