Drug interactions
Ampicillin + Rabeprazole
Severity: Minor
Ampicillin and Rabeprazole: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Oral ampicillin absorption may be modestly lowered when gastric pH is raised by rabeprazole. This is of limited clinical importance in most patients but could matter in serious infections.
What this interaction means in plain words
Ampicillin and Rabeprazole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Ampicillin belongs to Anti Bacterial; Rabeprazole belongs to Gastrointestinal Tract.
Why it happens
Increased gastric pH may alter dissolution and absorption of oral ampicillin.
What to do
No routine adjustment is needed; if oral ampicillin is failing clinically, consider whether acid suppression is necessary or choose an alternative agent.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Rabeprazole
- Rabeprazole + Rilpivirine Contraindicated
- Acalabrutinib + Rabeprazole Major
- Atazanavir + Rabeprazole Major
- Dacomitinib + Rabeprazole Major
- Dasatinib + Rabeprazole Major
- Erlotinib + Rabeprazole Major
Other interactions of Ampicillin
- Allopurinol + Ampicillin Moderate
- Ampicillin + Bcg vaccine live Moderate
- Ampicillin + Chloramphenicol Moderate
- Ampicillin + Chloroquine Moderate
- Ampicillin + Cholera vaccine Moderate
- Ampicillin + Demeclocycline Moderate
Frequently asked questions
Can I take Ampicillin with Rabeprazole?
MediHelp rates the interaction as minor. Ampicillin and Rabeprazole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Oral ampicillin absorption may be modestly lowered when gastric pH is raised by rabeprazole. This is of limited clinical importance in most patients but could matter in serious infections.
How serious is the interaction between Ampicillin and Rabeprazole?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine adjustment is needed; if oral ampicillin is failing clinically, consider whether acid suppression is necessary or choose an alternative agent.
What other medicines interact with Rabeprazole?
MediHelp also lists interactions of Rabeprazole with, for example, Rilpivirine, Acalabrutinib, Atazanavir. The full list is on the Rabeprazole page.
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