Drug interactions
Ampicillin + Sodium phenylacetate
Severity: Minor
Ampicillin and Sodium phenylacetate: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs are organic anions eliminated by renal tubular secretion, so they may compete for the same transport pathways. This could modestly slow clearance of either agent, though clinical significance is uncertain.
What this interaction means in plain words
Ampicillin and Sodium phenylacetate have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Possible competition for renal tubular organic anion secretion.
What to do
No dose change is routinely needed; monitor ammonia and neurologic status in hyperammonemia patients and watch for beta-lactam adverse effects in renal impairment.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Ampicillin
- Allopurinol + Ampicillin Moderate
- Ampicillin + Bcg vaccine live Moderate
- Ampicillin + Chloramphenicol Moderate
- Ampicillin + Chloroquine Moderate
- Ampicillin + Cholera vaccine Moderate
- Ampicillin + Demeclocycline Moderate
Frequently asked questions
Can I take Ampicillin with Sodium phenylacetate?
MediHelp rates the interaction as minor. Ampicillin and Sodium phenylacetate have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Both drugs are organic anions eliminated by renal tubular secretion, so they may compete for the same transport pathways. This could modestly slow clearance of either agent, though clinical significance is uncertain.
How serious is the interaction between Ampicillin and Sodium phenylacetate?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is routinely needed; monitor ammonia and neurologic status in hyperammonemia patients and watch for beta-lactam adverse effects in renal impairment.
What other medicines interact with Ampicillin?
MediHelp also lists interactions of Ampicillin with, for example, Allopurinol, Bcg vaccine live, Chloramphenicol. The full list is on the Ampicillin page.
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