Drug interactions
Ampicillin-sulbactam + Choline magnesium trisalicylate
Severity: Minor
Ampicillin-sulbactam and Choline magnesium trisalicylate: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Salicylates can compete with penicillins for renal tubular secretion and for protein binding, which may modestly raise penicillin exposure. The clinical effect is usually small because penicillins have a wide therapeutic margin.
What this interaction means in plain words
Ampicillin-sulbactam and Choline magnesium trisalicylate have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Competition for renal tubular organic anion secretion and plasma protein binding sites.
What to do
No routine dose change is needed; watch for penicillin adverse effects such as rash or GI upset in patients with renal impairment or on high-dose salicylate.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Ampicillin-sulbactam
Frequently asked questions
Can I take Ampicillin-sulbactam with Choline magnesium trisalicylate?
MediHelp rates the interaction as minor. Ampicillin-sulbactam and Choline magnesium trisalicylate have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Salicylates can compete with penicillins for renal tubular secretion and for protein binding, which may modestly raise penicillin exposure. The clinical effect is usually small because penicillins have a wide therapeutic margin.
How serious is the interaction between Ampicillin-sulbactam and Choline magnesium trisalicylate?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine dose change is needed; watch for penicillin adverse effects such as rash or GI upset in patients with renal impairment or on high-dose salicylate.
What other medicines interact with Ampicillin-sulbactam?
MediHelp also lists interactions of Ampicillin-sulbactam with, for example, Methotrexate, Allopurinol, Bcg vaccine live. The full list is on the Ampicillin-sulbactam page.
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