Drug interactions
Ampicillin-sulbactam + Sodium phenylacetate
Severity: Minor
Ampicillin-sulbactam and Sodium phenylacetate: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both ampicillin and phenylacetate are organic anions eliminated by renal tubular secretion, so they may compete for excretion. Higher exposure to either drug is theoretically possible, though clinical data are scarce.
What this interaction means in plain words
Ampicillin-sulbactam and Sodium phenylacetate have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Possible competition for renal tubular organic anion transport.
What to do
No empirical dose change; monitor ammonia and plasma levels of phenylacetate and for neurotoxicity in patients with renal impairment.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Ampicillin-sulbactam
Frequently asked questions
Can I take Ampicillin-sulbactam with Sodium phenylacetate?
MediHelp rates the interaction as minor. Ampicillin-sulbactam and Sodium phenylacetate have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Both ampicillin and phenylacetate are organic anions eliminated by renal tubular secretion, so they may compete for excretion. Higher exposure to either drug is theoretically possible, though clinical data are scarce.
How serious is the interaction between Ampicillin-sulbactam and Sodium phenylacetate?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No empirical dose change; monitor ammonia and plasma levels of phenylacetate and for neurotoxicity in patients with renal impairment.
What other medicines interact with Ampicillin-sulbactam?
MediHelp also lists interactions of Ampicillin-sulbactam with, for example, Methotrexate, Allopurinol, Bcg vaccine live. The full list is on the Ampicillin-sulbactam page.
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