Drug interactions
Ampicillin-sulbactam + Willow bark
Severity: Minor
Ampicillin-sulbactam and Willow bark: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Willow bark contains salicin, converted to salicylates, which may compete with penicillins for renal tubular secretion. The effect on ampicillin levels is probably small, and willow bark also carries salicylate-type bleeding considerations.
What this interaction means in plain words
Ampicillin-sulbactam and Willow bark have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Possible competition of salicylates for renal tubular secretion of penicillins.
What to do
No routine adjustment; monitor for penicillin adverse effects in renal impairment.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Ampicillin-sulbactam
Frequently asked questions
Can I take Ampicillin-sulbactam with Willow bark?
MediHelp rates the interaction as minor. Ampicillin-sulbactam and Willow bark have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Willow bark contains salicin, converted to salicylates, which may compete with penicillins for renal tubular secretion. The effect on ampicillin levels is probably small, and willow bark also carries salicylate-type bleeding considerations.
How serious is the interaction between Ampicillin-sulbactam and Willow bark?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine adjustment; monitor for penicillin adverse effects in renal impairment.
What other medicines interact with Ampicillin-sulbactam?
MediHelp also lists interactions of Ampicillin-sulbactam with, for example, Methotrexate, Allopurinol, Bcg vaccine live. The full list is on the Ampicillin-sulbactam page.
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