Drug interactions
Amyl nitrite + Benazepril
Severity: Moderate
Amyl nitrite and Benazepril: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Amyl nitrite is a potent vasodilator, and benazepril lowers blood pressure, so combined use can cause additive hypotension with dizziness or syncope. The effect is usually short-lived given amyl nitrite's brief action.
What this interaction means in plain words
Amyl nitrite and Benazepril can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive vasodilation through nitric oxide-mediated venodilation and ACE inhibition.
What to do
Use amyl nitrite with the patient seated or lying down, and monitor blood pressure. Counsel on postural hypotension.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Benazepril
- Aliskiren + Benazepril Contraindicated
- Benazepril + Sacubitril / valsartan Contraindicated
- Benazepril + Sacubitril-valsartan Contraindicated
- Amifostine + Benazepril Major
- Amiloride + Benazepril Major
- Amlodipine-hydrochlorothiazide-valsartan + Benazepril Major
Frequently asked questions
Can I take Amyl nitrite with Benazepril?
MediHelp rates the interaction as moderate. Amyl nitrite and Benazepril can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Amyl nitrite is a potent vasodilator, and benazepril lowers blood pressure, so combined use can cause additive hypotension with dizziness or syncope. The effect is usually short-lived given amyl nitrite's brief action.
How serious is the interaction between Amyl nitrite and Benazepril?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use amyl nitrite with the patient seated or lying down, and monitor blood pressure. Counsel on postural hypotension.
What other medicines interact with Benazepril?
MediHelp also lists interactions of Benazepril with, for example, Aliskiren, Sacubitril / valsartan, Sacubitril-valsartan. The full list is on the Benazepril page.
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