Drug interactions
Amyl nitrite + Captopril-hydrochlorothiazide
Severity: Moderate
Amyl nitrite and Captopril-hydrochlorothiazide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Amyl nitrite is a potent vasodilator, and combined with captopril and hydrochlorothiazide it can cause additive hypotension, dizziness, and syncope. The risk is greater with volume depletion or upright posture.
What this interaction means in plain words
Amyl nitrite and Captopril-hydrochlorothiazide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive vasodilation and blood pressure lowering from nitrate venodilation together with ACE inhibition and diuretic-induced volume reduction.
What to do
Advise patients to sit or lie down when using amyl nitrite and monitor blood pressure. Avoid in patients who are hypotensive or volume depleted.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Captopril-hydrochlorothiazide
- Aliskiren + Captopril-hydrochlorothiazide Contraindicated
- Captopril-hydrochlorothiazide + Dofetilide Contraindicated
- Captopril-hydrochlorothiazide + Sacubitril / valsartan Contraindicated
- Aceclofenac + Captopril-hydrochlorothiazide Major
- Aldesleukin + Captopril-hydrochlorothiazide Major
- Amifostine + Captopril-hydrochlorothiazide Major
Frequently asked questions
Can I take Amyl nitrite with Captopril-hydrochlorothiazide?
MediHelp rates the interaction as moderate. Amyl nitrite and Captopril-hydrochlorothiazide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Amyl nitrite is a potent vasodilator, and combined with captopril and hydrochlorothiazide it can cause additive hypotension, dizziness, and syncope. The risk is greater with volume depletion or upright posture.
How serious is the interaction between Amyl nitrite and Captopril-hydrochlorothiazide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Advise patients to sit or lie down when using amyl nitrite and monitor blood pressure. Avoid in patients who are hypotensive or volume depleted.
What other medicines interact with Captopril-hydrochlorothiazide?
MediHelp also lists interactions of Captopril-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Sacubitril / valsartan. The full list is on the Captopril-hydrochlorothiazide page.
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