Drug interactions
Anagrelide + Artemether / lumefantrine
Severity: Major
Anagrelide and Artemether / lumefantrine: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Artemether/lumefantrine can prolong the QT interval, and anagrelide has the same effect, so the combination may lead to clinically significant QTc lengthening and torsades de pointes. Lumefantrine has a long half-life, so the risk persists for days after the last dose.
What this interaction means in plain words
Anagrelide and Artemether / lumefantrine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Additive pharmacodynamic prolongation of cardiac repolarization.
What to do
Avoid the combination where possible; consider another antimalarial. If it must be used, check an ECG at baseline and during therapy and correct electrolyte abnormalities.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Anagrelide
- Anagrelide + Panobinostat Contraindicated
- Anagrelide + Pimozide Contraindicated
- Anagrelide + Thioridazine Contraindicated
- Anagrelide + Vandetanib Contraindicated
- Abrocitinib + Anagrelide Major
- Alfuzosin + Anagrelide Major
Frequently asked questions
Can I take Anagrelide with Artemether / lumefantrine?
MediHelp rates the interaction as major. Anagrelide and Artemether / lumefantrine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Artemether/lumefantrine can prolong the QT interval, and anagrelide has the same effect, so the combination may lead to clinically significant QTc lengthening and torsades de pointes. Lumefantrine has a long half-life, so the risk persists for days after the last dose.
How serious is the interaction between Anagrelide and Artemether / lumefantrine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination where possible; consider another antimalarial. If it must be used, check an ECG at baseline and during therapy and correct electrolyte abnormalities.
What other medicines interact with Anagrelide?
MediHelp also lists interactions of Anagrelide with, for example, Panobinostat, Pimozide, Thioridazine. The full list is on the Anagrelide page.
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