Drug interactions
Anagrelide + Asenapine transdermal
Severity: Major
Anagrelide and Asenapine transdermal: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Asenapine can prolong the QT interval and anagrelide shares this effect, so concurrent use may increase the risk of serious ventricular arrhythmia. The concern is greater in patients with cardiac disease, bradycardia or electrolyte disturbances.
What this interaction means in plain words
Anagrelide and Asenapine transdermal can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Additive pharmacodynamic prolongation of the QT interval.
What to do
Avoid the combination if possible, or obtain a baseline ECG and repeat after starting or changing doses while keeping potassium and magnesium normal.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Anagrelide
- Anagrelide + Panobinostat Contraindicated
- Anagrelide + Pimozide Contraindicated
- Anagrelide + Thioridazine Contraindicated
- Anagrelide + Vandetanib Contraindicated
- Abrocitinib + Anagrelide Major
- Alfuzosin + Anagrelide Major
Frequently asked questions
Can I take Anagrelide with Asenapine transdermal?
MediHelp rates the interaction as major. Anagrelide and Asenapine transdermal can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Asenapine can prolong the QT interval and anagrelide shares this effect, so concurrent use may increase the risk of serious ventricular arrhythmia. The concern is greater in patients with cardiac disease, bradycardia or electrolyte disturbances.
How serious is the interaction between Anagrelide and Asenapine transdermal?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination if possible, or obtain a baseline ECG and repeat after starting or changing doses while keeping potassium and magnesium normal.
What other medicines interact with Anagrelide?
MediHelp also lists interactions of Anagrelide with, for example, Panobinostat, Pimozide, Thioridazine. The full list is on the Anagrelide page.
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