Drug interactions
Anagrelide + Aspirin / citric acid / sodium bicarbonate
Severity: Moderate
Anagrelide and Aspirin / citric acid / sodium bicarbonate: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
The aspirin in this effervescent product adds antiplatelet effect to that of anagrelide, which raises the risk of bleeding, particularly gastrointestinal bleeding. Analgesic-dose aspirin carries more risk than low-dose aspirin.
What this interaction means in plain words
Anagrelide and Aspirin / citric acid / sodium bicarbonate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive antiplatelet effects: anagrelide inhibits platelet aggregation and aspirin inhibits platelet cyclooxygenase.
What to do
Avoid regular analgesic-dose aspirin unless clearly needed, and monitor for bleeding signs and blood counts. Use paracetamol for pain where suitable.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Anagrelide
- Anagrelide + Panobinostat Contraindicated
- Anagrelide + Pimozide Contraindicated
- Anagrelide + Thioridazine Contraindicated
- Anagrelide + Vandetanib Contraindicated
- Abrocitinib + Anagrelide Major
- Alfuzosin + Anagrelide Major
Frequently asked questions
Can I take Anagrelide with Aspirin / citric acid / sodium bicarbonate?
MediHelp rates the interaction as moderate. Anagrelide and Aspirin / citric acid / sodium bicarbonate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. The aspirin in this effervescent product adds antiplatelet effect to that of anagrelide, which raises the risk of bleeding, particularly gastrointestinal bleeding. Analgesic-dose aspirin carries more risk than low-dose aspirin.
How serious is the interaction between Anagrelide and Aspirin / citric acid / sodium bicarbonate?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid regular analgesic-dose aspirin unless clearly needed, and monitor for bleeding signs and blood counts. Use paracetamol for pain where suitable.
What other medicines interact with Anagrelide?
MediHelp also lists interactions of Anagrelide with, for example, Panobinostat, Pimozide, Thioridazine. The full list is on the Anagrelide page.
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