Drug interactions
Anagrelide + Aspirin rectal
Severity: Moderate
Anagrelide and Aspirin rectal: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Anagrelide inhibits platelet aggregation and aspirin irreversibly inhibits platelet cyclooxygenase, so together they increase the tendency to bleeding, particularly gastrointestinal bleeding. Aspirin is often used deliberately with anagrelide in essential thrombocythemia, but the added bleeding risk still needs consideration.
What this interaction means in plain words
Anagrelide and Aspirin rectal can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive antiplatelet effects through different pathways (PDE3 inhibition with anagrelide and COX-1 inhibition with aspirin).
What to do
Use the combination only when there is a clear indication and review the aspirin dose and need. Monitor for bleeding and check the platelet count and hemoglobin regularly.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Anagrelide
- Anagrelide + Panobinostat Contraindicated
- Anagrelide + Pimozide Contraindicated
- Anagrelide + Thioridazine Contraindicated
- Anagrelide + Vandetanib Contraindicated
- Abrocitinib + Anagrelide Major
- Alfuzosin + Anagrelide Major
Frequently asked questions
Can I take Anagrelide with Aspirin rectal?
MediHelp rates the interaction as moderate. Anagrelide and Aspirin rectal can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Anagrelide inhibits platelet aggregation and aspirin irreversibly inhibits platelet cyclooxygenase, so together they increase the tendency to bleeding, particularly gastrointestinal bleeding. Aspirin is often used deliberately with anagrelide in essential thrombocythemia, but the added bleeding risk still needs consideration.
How serious is the interaction between Anagrelide and Aspirin rectal?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the combination only when there is a clear indication and review the aspirin dose and need. Monitor for bleeding and check the platelet count and hemoglobin regularly.
What other medicines interact with Anagrelide?
MediHelp also lists interactions of Anagrelide with, for example, Panobinostat, Pimozide, Thioridazine. The full list is on the Anagrelide page.
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