Drug interactions
Anagrelide + Atomoxetine
Severity: Moderate
Anagrelide and Atomoxetine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Anagrelide can prolong the QT interval and cause tachycardia and palpitations, and atomoxetine has been associated with QT effects and heart rate increases. Combined use may add to arrhythmia risk, particularly with other risk factors.
What this interaction means in plain words
Anagrelide and Atomoxetine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Anagrelide belongs to Cardiovascular; Atomoxetine belongs to Central Nervous System.
Why it happens
Additive QT prolongation and cardiovascular stimulation (pharmacodynamic).
What to do
Obtain a baseline ECG and correct potassium and magnesium before combining. Monitor ECG and symptoms such as palpitations or syncope.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Atomoxetine
- Atomoxetine + Isocarboxazid Contraindicated
- Atomoxetine + Linezolid Contraindicated
- Atomoxetine + Phenelzine Contraindicated
- Atomoxetine + Procarbazine Contraindicated
- Atomoxetine + Rasagiline Contraindicated
- Atomoxetine + Selegiline Contraindicated
Other interactions of Anagrelide
- Anagrelide + Panobinostat Contraindicated
- Anagrelide + Pimozide Contraindicated
- Anagrelide + Thioridazine Contraindicated
- Anagrelide + Vandetanib Contraindicated
- Abrocitinib + Anagrelide Major
- Alfuzosin + Anagrelide Major
Frequently asked questions
Can I take Anagrelide with Atomoxetine?
MediHelp rates the interaction as moderate. Anagrelide and Atomoxetine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Anagrelide can prolong the QT interval and cause tachycardia and palpitations, and atomoxetine has been associated with QT effects and heart rate increases. Combined use may add to arrhythmia risk, particularly with other risk factors.
How serious is the interaction between Anagrelide and Atomoxetine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain a baseline ECG and correct potassium and magnesium before combining. Monitor ECG and symptoms such as palpitations or syncope.
What other medicines interact with Atomoxetine?
MediHelp also lists interactions of Atomoxetine with, for example, Isocarboxazid, Linezolid, Phenelzine. The full list is on the Atomoxetine page.
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