Drug interactions
Anagrelide + Buprenorphine buccal
Severity: Moderate
Anagrelide and Buprenorphine buccal: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Buprenorphine can prolong the QTc interval, with the effect being dose-related and most relevant for higher-exposure formulations, and anagrelide adds to this effect. The combination may increase arrhythmia risk in susceptible patients.
What this interaction means in plain words
Anagrelide and Buprenorphine buccal can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive pharmacodynamic prolongation of the QT interval.
What to do
Obtain a baseline ECG and repeat after dose changes, especially in patients with cardiac risk factors. Correct electrolyte abnormalities and consider alternatives if QTc rises significantly.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Anagrelide
- Anagrelide + Panobinostat Contraindicated
- Anagrelide + Pimozide Contraindicated
- Anagrelide + Thioridazine Contraindicated
- Anagrelide + Vandetanib Contraindicated
- Abrocitinib + Anagrelide Major
- Alfuzosin + Anagrelide Major
Frequently asked questions
Can I take Anagrelide with Buprenorphine buccal?
MediHelp rates the interaction as moderate. Anagrelide and Buprenorphine buccal can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Buprenorphine can prolong the QTc interval, with the effect being dose-related and most relevant for higher-exposure formulations, and anagrelide adds to this effect. The combination may increase arrhythmia risk in susceptible patients.
How serious is the interaction between Anagrelide and Buprenorphine buccal?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain a baseline ECG and repeat after dose changes, especially in patients with cardiac risk factors. Correct electrolyte abnormalities and consider alternatives if QTc rises significantly.
What other medicines interact with Anagrelide?
MediHelp also lists interactions of Anagrelide with, for example, Panobinostat, Pimozide, Thioridazine. The full list is on the Anagrelide page.
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