Drug interactions
Anagrelide + Buprenorphine long-acting
Severity: Moderate
Anagrelide and Buprenorphine long-acting: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Buprenorphine can prolong the QTc interval, and anagrelide has a similar effect, so the combination may add to arrhythmia risk. Long-acting injection leads to sustained exposure, so the effect cannot be quickly reversed.
What this interaction means in plain words
Anagrelide and Buprenorphine long-acting can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive pharmacodynamic prolongation of the QT interval.
What to do
Obtain a baseline ECG and monitor QTc during co-therapy, particularly in patients with cardiac risk factors. Correct potassium and magnesium abnormalities.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Anagrelide
- Anagrelide + Panobinostat Contraindicated
- Anagrelide + Pimozide Contraindicated
- Anagrelide + Thioridazine Contraindicated
- Anagrelide + Vandetanib Contraindicated
- Abrocitinib + Anagrelide Major
- Alfuzosin + Anagrelide Major
Frequently asked questions
Can I take Anagrelide with Buprenorphine long-acting?
MediHelp rates the interaction as moderate. Anagrelide and Buprenorphine long-acting can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Buprenorphine can prolong the QTc interval, and anagrelide has a similar effect, so the combination may add to arrhythmia risk. Long-acting injection leads to sustained exposure, so the effect cannot be quickly reversed.
How serious is the interaction between Anagrelide and Buprenorphine long-acting?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain a baseline ECG and monitor QTc during co-therapy, particularly in patients with cardiac risk factors. Correct potassium and magnesium abnormalities.
What other medicines interact with Anagrelide?
MediHelp also lists interactions of Anagrelide with, for example, Panobinostat, Pimozide, Thioridazine. The full list is on the Anagrelide page.
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