Drug interactions
Anagrelide + Buprenorphine subdermal implant
Severity: Moderate
Anagrelide and Buprenorphine subdermal implant: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Buprenorphine can modestly prolong the QTc interval and anagrelide may add to this effect. The risk is mainly relevant in patients with other arrhythmia risk factors.
What this interaction means in plain words
Anagrelide and Buprenorphine subdermal implant can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive pharmacodynamic prolongation of the QT interval.
What to do
Obtain a baseline ECG and monitor QTc during co-therapy in patients with cardiac risk factors. Keep potassium and magnesium normal.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Anagrelide
- Anagrelide + Panobinostat Contraindicated
- Anagrelide + Pimozide Contraindicated
- Anagrelide + Thioridazine Contraindicated
- Anagrelide + Vandetanib Contraindicated
- Abrocitinib + Anagrelide Major
- Alfuzosin + Anagrelide Major
Frequently asked questions
Can I take Anagrelide with Buprenorphine subdermal implant?
MediHelp rates the interaction as moderate. Anagrelide and Buprenorphine subdermal implant can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Buprenorphine can modestly prolong the QTc interval and anagrelide may add to this effect. The risk is mainly relevant in patients with other arrhythmia risk factors.
How serious is the interaction between Anagrelide and Buprenorphine subdermal implant?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain a baseline ECG and monitor QTc during co-therapy in patients with cardiac risk factors. Keep potassium and magnesium normal.
What other medicines interact with Anagrelide?
MediHelp also lists interactions of Anagrelide with, for example, Panobinostat, Pimozide, Thioridazine. The full list is on the Anagrelide page.
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