Drug interactions
Anagrelide + Buprenorphine transdermal
Severity: Moderate
Anagrelide and Buprenorphine transdermal: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Transdermal buprenorphine carries labeling for dose-related QTc prolongation, and anagrelide may add to this effect. Together they may increase the risk of ventricular arrhythmia in susceptible patients.
What this interaction means in plain words
Anagrelide and Buprenorphine transdermal can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive pharmacodynamic prolongation of the QT interval.
What to do
Check a baseline ECG and repeat after dose changes, and keep the buprenorphine dose as low as effective. Correct electrolyte disturbances and consider an alternative analgesic if QTc lengthens significantly.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Anagrelide and Buprenorphine transdermal, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Anagrelide
- Anagrelide + Panobinostat Contraindicated
- Anagrelide + Pimozide Contraindicated
- Anagrelide + Thioridazine Contraindicated
- Anagrelide + Vandetanib Contraindicated
- Abrocitinib + Anagrelide Major
- Alfuzosin + Anagrelide Major
Frequently asked questions
Can I take Anagrelide with Buprenorphine transdermal?
MediHelp rates the interaction as moderate. Anagrelide and Buprenorphine transdermal can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Transdermal buprenorphine carries labeling for dose-related QTc prolongation, and anagrelide may add to this effect. Together they may increase the risk of ventricular arrhythmia in susceptible patients.
How serious is the interaction between Anagrelide and Buprenorphine transdermal?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check a baseline ECG and repeat after dose changes, and keep the buprenorphine dose as low as effective. Correct electrolyte disturbances and consider an alternative analgesic if QTc lengthens significantly.
What other medicines interact with Anagrelide?
MediHelp also lists interactions of Anagrelide with, for example, Panobinostat, Pimozide, Thioridazine. The full list is on the Anagrelide page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
