Drug interactions
Anagrelide + Droperidol
Severity: Major
Anagrelide and Droperidol: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Droperidol has a boxed warning for QT prolongation and torsades de pointes, and anagrelide can also lengthen the QT interval. The combination substantially increases the risk of serious arrhythmia.
What this interaction means in plain words
Anagrelide and Droperidol can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Additive pharmacodynamic prolongation of the QT interval.
What to do
Avoid droperidol in patients taking anagrelide and use a non-QT-prolonging antiemetic or sedative. If unavoidable, obtain an ECG beforehand and monitor continuously.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Anagrelide
- Anagrelide + Panobinostat Contraindicated
- Anagrelide + Pimozide Contraindicated
- Anagrelide + Thioridazine Contraindicated
- Anagrelide + Vandetanib Contraindicated
- Abrocitinib + Anagrelide Major
- Alfuzosin + Anagrelide Major
Frequently asked questions
Can I take Anagrelide with Droperidol?
MediHelp rates the interaction as major. Anagrelide and Droperidol can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Droperidol has a boxed warning for QT prolongation and torsades de pointes, and anagrelide can also lengthen the QT interval. The combination substantially increases the risk of serious arrhythmia.
How serious is the interaction between Anagrelide and Droperidol?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid droperidol in patients taking anagrelide and use a non-QT-prolonging antiemetic or sedative. If unavoidable, obtain an ECG beforehand and monitor continuously.
What other medicines interact with Anagrelide?
MediHelp also lists interactions of Anagrelide with, for example, Panobinostat, Pimozide, Thioridazine. The full list is on the Anagrelide page.
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