Drug interactions
Anagrelide + Erythromycin ethylsuccinate
Severity: Major
Anagrelide and Erythromycin ethylsuccinate: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Erythromycin ethylsuccinate carries the macrolide risk of QT prolongation and torsades de pointes, and anagrelide adds to this effect. The combination increases the risk of serious ventricular arrhythmia.
What this interaction means in plain words
Anagrelide and Erythromycin ethylsuccinate can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Additive pharmacodynamic prolongation of the QT interval.
What to do
Use a non-QT-prolonging antibiotic if possible. If the macrolide is needed, perform an ECG and correct electrolyte abnormalities.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Anagrelide
- Anagrelide + Panobinostat Contraindicated
- Anagrelide + Pimozide Contraindicated
- Anagrelide + Thioridazine Contraindicated
- Anagrelide + Vandetanib Contraindicated
- Abrocitinib + Anagrelide Major
- Alfuzosin + Anagrelide Major
Frequently asked questions
Can I take Anagrelide with Erythromycin ethylsuccinate?
MediHelp rates the interaction as major. Anagrelide and Erythromycin ethylsuccinate can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Erythromycin ethylsuccinate carries the macrolide risk of QT prolongation and torsades de pointes, and anagrelide adds to this effect. The combination increases the risk of serious ventricular arrhythmia.
How serious is the interaction between Anagrelide and Erythromycin ethylsuccinate?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use a non-QT-prolonging antibiotic if possible. If the macrolide is needed, perform an ECG and correct electrolyte abnormalities.
What other medicines interact with Anagrelide?
MediHelp also lists interactions of Anagrelide with, for example, Panobinostat, Pimozide, Thioridazine. The full list is on the Anagrelide page.
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