Drug interactions
Anagrelide + Inamrinone
Severity: Moderate
Anagrelide and Inamrinone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs are PDE3 inhibitors. Combined use can add to vasodilation, hypotension, tachycardia and arrhythmia, and inamrinone can cause thrombocytopenia, which complicates anagrelide's platelet-lowering effect.
What this interaction means in plain words
Anagrelide and Inamrinone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive PDE3 inhibition with cardiovascular and platelet effects.
What to do
Monitor blood pressure, heart rhythm and platelet counts. Consider whether anagrelide can be held during inamrinone therapy.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Anagrelide
- Anagrelide + Panobinostat Contraindicated
- Anagrelide + Pimozide Contraindicated
- Anagrelide + Thioridazine Contraindicated
- Anagrelide + Vandetanib Contraindicated
- Abrocitinib + Anagrelide Major
- Alfuzosin + Anagrelide Major
Frequently asked questions
Can I take Anagrelide with Inamrinone?
MediHelp rates the interaction as moderate. Anagrelide and Inamrinone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs are PDE3 inhibitors. Combined use can add to vasodilation, hypotension, tachycardia and arrhythmia, and inamrinone can cause thrombocytopenia, which complicates anagrelide's platelet-lowering effect.
How serious is the interaction between Anagrelide and Inamrinone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, heart rhythm and platelet counts. Consider whether anagrelide can be held during inamrinone therapy.
What other medicines interact with Anagrelide?
MediHelp also lists interactions of Anagrelide with, for example, Panobinostat, Pimozide, Thioridazine. The full list is on the Anagrelide page.
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