Drug interactions
Anagrelide + Lithium
Severity: Moderate
Anagrelide and Lithium: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Anagrelide can prolong the QT interval and cause tachyarrhythmias, and lithium has been associated with QT changes and sinus node dysfunction. Together they may increase arrhythmia risk, particularly in patients with cardiac disease.
What this interaction means in plain words
Anagrelide and Lithium can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Anagrelide belongs to Cardiovascular; Lithium belongs to Central Nervous System.
Why it happens
Additive effects on cardiac repolarization leading to QT prolongation.
What to do
Obtain a baseline ECG and monitor it after starting the combination, and correct potassium and magnesium. Avoid in patients with congenital long QT or other QT-prolonging drugs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Lithium
- Lithium + Thioridazine Contraindicated
- Lithium + Vandetanib Contraindicated
- Aceclofenac + Lithium Major
- Acemetacin + Lithium Major
- Amisulpride + Lithium Major
- Amlodipine-benazepril + Lithium Major
Other interactions of Anagrelide
- Anagrelide + Panobinostat Contraindicated
- Anagrelide + Pimozide Contraindicated
- Anagrelide + Thioridazine Contraindicated
- Anagrelide + Vandetanib Contraindicated
- Abrocitinib + Anagrelide Major
- Alfuzosin + Anagrelide Major
Frequently asked questions
Can I take Anagrelide with Lithium?
MediHelp rates the interaction as moderate. Anagrelide and Lithium can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Anagrelide can prolong the QT interval and cause tachyarrhythmias, and lithium has been associated with QT changes and sinus node dysfunction. Together they may increase arrhythmia risk, particularly in patients with cardiac disease.
How serious is the interaction between Anagrelide and Lithium?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain a baseline ECG and monitor it after starting the combination, and correct potassium and magnesium. Avoid in patients with congenital long QT or other QT-prolonging drugs.
What other medicines interact with Lithium?
MediHelp also lists interactions of Lithium with, for example, Thioridazine, Vandetanib, Aceclofenac. The full list is on the Lithium page.
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