Drug interactions
Anagrelide + Octreotide
Severity: Moderate
Anagrelide and Octreotide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Anagrelide can prolong the QT interval and cause tachycardia and palpitations, and octreotide may add QT prolongation and bradycardia. Together they may raise arrhythmia risk.
What this interaction means in plain words
Anagrelide and Octreotide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Anagrelide belongs to Cardiovascular; Octreotide belongs to Endocrine.
Why it happens
Additive QT prolongation.
What to do
Obtain a baseline ECG and monitor periodically, correcting potassium and magnesium. Reassess therapy if QTc becomes markedly prolonged.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Octreotide
Other interactions of Anagrelide
- Anagrelide + Panobinostat Contraindicated
- Anagrelide + Pimozide Contraindicated
- Anagrelide + Thioridazine Contraindicated
- Anagrelide + Vandetanib Contraindicated
- Abrocitinib + Anagrelide Major
- Alfuzosin + Anagrelide Major
Frequently asked questions
Can I take Anagrelide with Octreotide?
MediHelp rates the interaction as moderate. Anagrelide and Octreotide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Anagrelide can prolong the QT interval and cause tachycardia and palpitations, and octreotide may add QT prolongation and bradycardia. Together they may raise arrhythmia risk.
How serious is the interaction between Anagrelide and Octreotide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain a baseline ECG and monitor periodically, correcting potassium and magnesium. Reassess therapy if QTc becomes markedly prolonged.
What other medicines interact with Octreotide?
MediHelp also lists interactions of Octreotide with, for example, Adagrasib, Amisulpride, Arsenic trioxide. The full list is on the Octreotide page.
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