Drug interactions
Anagrelide + Olanzapine
Severity: Moderate
Anagrelide and Olanzapine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Anagrelide can prolong the QT interval and cause tachycardia and palpitations, and olanzapine has a small QT effect. The combination may add to arrhythmia risk.
What this interaction means in plain words
Anagrelide and Olanzapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Anagrelide belongs to Cardiovascular; Olanzapine belongs to Central Nervous System.
Why it happens
Additive QT prolongation; olanzapine's effect is modest.
What to do
Obtain baseline ECG and correct potassium and magnesium before combining. Repeat ECG after initiation and with dose changes.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Olanzapine
Other interactions of Anagrelide
- Anagrelide + Panobinostat Contraindicated
- Anagrelide + Pimozide Contraindicated
- Anagrelide + Thioridazine Contraindicated
- Anagrelide + Vandetanib Contraindicated
- Abrocitinib + Anagrelide Major
- Alfuzosin + Anagrelide Major
Frequently asked questions
Can I take Anagrelide with Olanzapine?
MediHelp rates the interaction as moderate. Anagrelide and Olanzapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Anagrelide can prolong the QT interval and cause tachycardia and palpitations, and olanzapine has a small QT effect. The combination may add to arrhythmia risk.
How serious is the interaction between Anagrelide and Olanzapine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain baseline ECG and correct potassium and magnesium before combining. Repeat ECG after initiation and with dose changes.
What other medicines interact with Olanzapine?
MediHelp also lists interactions of Olanzapine with, for example, Amisulpride, Amoxapine, Apomorphine. The full list is on the Olanzapine page.
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