Drug interactions
Anagrelide + Protriptyline
Severity: Moderate
Anagrelide and Protriptyline: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs can prolong the QT interval, and protriptyline, a tricyclic antidepressant, also slows cardiac conduction and raises heart rate. Combined use may increase the risk of ventricular arrhythmias.
What this interaction means in plain words
Anagrelide and Protriptyline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive QT prolongation and effects on cardiac conduction.
What to do
Obtain a baseline ECG and monitor the QTc and electrolytes. Choose an alternative antidepressant in patients with cardiac disease.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Anagrelide
- Anagrelide + Panobinostat Contraindicated
- Anagrelide + Pimozide Contraindicated
- Anagrelide + Thioridazine Contraindicated
- Anagrelide + Vandetanib Contraindicated
- Abrocitinib + Anagrelide Major
- Alfuzosin + Anagrelide Major
Frequently asked questions
Can I take Anagrelide with Protriptyline?
MediHelp rates the interaction as moderate. Anagrelide and Protriptyline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs can prolong the QT interval, and protriptyline, a tricyclic antidepressant, also slows cardiac conduction and raises heart rate. Combined use may increase the risk of ventricular arrhythmias.
How serious is the interaction between Anagrelide and Protriptyline?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain a baseline ECG and monitor the QTc and electrolytes. Choose an alternative antidepressant in patients with cardiac disease.
What other medicines interact with Anagrelide?
MediHelp also lists interactions of Anagrelide with, for example, Panobinostat, Pimozide, Thioridazine. The full list is on the Anagrelide page.
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