Drug interactions
Anagrelide + Selumetinib
Severity: Moderate
Anagrelide and Selumetinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Anagrelide inhibits platelet aggregation, and selumetinib carries a bleeding risk and contains vitamin E that may add to antiplatelet effects. Combined use may increase the risk of bleeding.
What this interaction means in plain words
Anagrelide and Selumetinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Anagrelide belongs to Cardiovascular; Selumetinib belongs to Oncology.
Why it happens
Additive antiplatelet effect of anagrelide with the bleeding tendency of selumetinib and its vitamin E content.
What to do
Monitor for bruising and bleeding and check platelet counts and coagulation parameters if on other antithrombotics. Avoid additional antiplatelet or anticoagulant drugs where possible.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Anagrelide
- Anagrelide + Panobinostat Contraindicated
- Anagrelide + Pimozide Contraindicated
- Anagrelide + Thioridazine Contraindicated
- Anagrelide + Vandetanib Contraindicated
- Abrocitinib + Anagrelide Major
- Alfuzosin + Anagrelide Major
Other interactions of Selumetinib
Frequently asked questions
Can I take Anagrelide with Selumetinib?
MediHelp rates the interaction as moderate. Anagrelide and Selumetinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Anagrelide inhibits platelet aggregation, and selumetinib carries a bleeding risk and contains vitamin E that may add to antiplatelet effects. Combined use may increase the risk of bleeding.
How serious is the interaction between Anagrelide and Selumetinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for bruising and bleeding and check platelet counts and coagulation parameters if on other antithrombotics. Avoid additional antiplatelet or anticoagulant drugs where possible.
What other medicines interact with Anagrelide?
MediHelp also lists interactions of Anagrelide with, for example, Panobinostat, Pimozide, Thioridazine. The full list is on the Anagrelide page.
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