Drug interactions
Anagrelide + Trifluoperazine
Severity: Moderate
Anagrelide and Trifluoperazine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Anagrelide and trifluoperazine can each prolong the QT interval, so combined use increases the chance of serious ventricular arrhythmias such as torsades de pointes. Patients with heart disease, electrolyte abnormalities or other QT-prolonging drugs are at greater risk.
What this interaction means in plain words
Anagrelide and Trifluoperazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive pharmacodynamic QT prolongation through delayed cardiac repolarization.
What to do
Check a baseline ECG and correct potassium and magnesium abnormalities before combining. Monitor the QTc periodically and reduce or stop one agent if significant prolongation occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Anagrelide
- Anagrelide + Panobinostat Contraindicated
- Anagrelide + Pimozide Contraindicated
- Anagrelide + Thioridazine Contraindicated
- Anagrelide + Vandetanib Contraindicated
- Abrocitinib + Anagrelide Major
- Alfuzosin + Anagrelide Major
Frequently asked questions
Can I take Anagrelide with Trifluoperazine?
MediHelp rates the interaction as moderate. Anagrelide and Trifluoperazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Anagrelide and trifluoperazine can each prolong the QT interval, so combined use increases the chance of serious ventricular arrhythmias such as torsades de pointes. Patients with heart disease, electrolyte abnormalities or other QT-prolonging drugs are at greater risk.
How serious is the interaction between Anagrelide and Trifluoperazine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check a baseline ECG and correct potassium and magnesium abnormalities before combining. Monitor the QTc periodically and reduce or stop one agent if significant prolongation occurs.
What other medicines interact with Anagrelide?
MediHelp also lists interactions of Anagrelide with, for example, Panobinostat, Pimozide, Thioridazine. The full list is on the Anagrelide page.
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