Drug interactions
Anagrelide + Venlafaxine
Severity: Moderate
Anagrelide and Venlafaxine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Anagrelide is associated with QT prolongation and tachyarrhythmias, and venlafaxine can also affect QT and raise heart rate. Concurrent use may increase the risk of arrhythmia; the legacy claim of QT shortening is incorrect.
What this interaction means in plain words
Anagrelide and Venlafaxine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Anagrelide belongs to Cardiovascular; Venlafaxine belongs to Central Nervous System.
Why it happens
Additive QT prolongation and cardiovascular stimulation.
What to do
Obtain a baseline ECG and monitor QTc and heart rate, correcting potassium and magnesium. Consider alternatives in patients with existing cardiac disease.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Venlafaxine
- Isocarboxazid + Venlafaxine Contraindicated
- Methylene blue + Venlafaxine Contraindicated
- Phenelzine + Venlafaxine Contraindicated
- Procarbazine + Venlafaxine Contraindicated
- Rasagiline + Venlafaxine Contraindicated
- Safinamide + Venlafaxine Contraindicated
Other interactions of Anagrelide
- Anagrelide + Panobinostat Contraindicated
- Anagrelide + Pimozide Contraindicated
- Anagrelide + Thioridazine Contraindicated
- Anagrelide + Vandetanib Contraindicated
- Abrocitinib + Anagrelide Major
- Alfuzosin + Anagrelide Major
Frequently asked questions
Can I take Anagrelide with Venlafaxine?
MediHelp rates the interaction as moderate. Anagrelide and Venlafaxine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Anagrelide is associated with QT prolongation and tachyarrhythmias, and venlafaxine can also affect QT and raise heart rate. Concurrent use may increase the risk of arrhythmia; the legacy claim of QT shortening is incorrect.
How serious is the interaction between Anagrelide and Venlafaxine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain a baseline ECG and monitor QTc and heart rate, correcting potassium and magnesium. Consider alternatives in patients with existing cardiac disease.
What other medicines interact with Venlafaxine?
MediHelp also lists interactions of Venlafaxine with, for example, Isocarboxazid, Methylene blue, Phenelzine. The full list is on the Venlafaxine page.
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