Drug interactions
Anakinra + Baricitinib
Severity: Major
Anakinra and Baricitinib: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Combined IL-1 blockade and JAK inhibition raises the risk of serious infection through overlapping immunosuppression. Baricitinib labeling advises against use with biologic DMARDs.
What this interaction means in plain words
Anakinra and Baricitinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Anakinra belongs to Musculoskeletal; Baricitinib belongs to Musculoskeletal.
Why it happens
Additive immunosuppression via IL-1 receptor antagonism and JAK inhibition.
What to do
Avoid the combination; use a single agent and monitor for infection.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Anakinra
- Anakinra + Bcg vaccine live Contraindicated
- Anakinra + Measles mumps and rubella vaccine Contraindicated
- Anakinra + Measles mumps and rubella vaccine live Contraindicated
- Anakinra + Measles mumps rubella and varicella vaccine live Contraindicated
- Anakinra + Measles vaccine Contraindicated
- Abatacept + Anakinra Major
Other interactions of Baricitinib
- Adenovirus types 4 and 7 live + Baricitinib Contraindicated
- Baricitinib + Bcg vaccine live Contraindicated
- Baricitinib + Tofacitinib Contraindicated
- Baricitinib + Upadacitinib Contraindicated
- Abatacept + Baricitinib Major
- Adalimumab + Baricitinib Major
Frequently asked questions
Can I take Anakinra with Baricitinib?
MediHelp rates the interaction as major. Anakinra and Baricitinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Combined IL-1 blockade and JAK inhibition raises the risk of serious infection through overlapping immunosuppression. Baricitinib labeling advises against use with biologic DMARDs.
How serious is the interaction between Anakinra and Baricitinib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination; use a single agent and monitor for infection.
What other medicines interact with Anakinra?
MediHelp also lists interactions of Anakinra with, for example, Bcg vaccine live, Measles mumps and rubella vaccine, Measles mumps and rubella vaccine live. The full list is on the Anakinra page.
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