Drug interactions
Anakinra + Tisagenlecleucel
Severity: Moderate
Anakinra and Tisagenlecleucel: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Anakinra is used off-label to manage CAR-T cytokine release syndrome and neurotoxicity, so the pairing is often intentional. The main concerns are added infection risk and a theoretical effect on CAR-T expansion and activity.
What this interaction means in plain words
Anakinra and Tisagenlecleucel can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Anakinra belongs to Musculoskeletal; Tisagenlecleucel belongs to Oncology.
Why it happens
IL-1 blockade may dampen inflammatory signaling and add to immunosuppression; effect on CAR-T efficacy is not firmly established.
What to do
Use anakinra for CAR-T toxicity only under specialist oversight and monitor for infection and for response of the underlying malignancy.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Anakinra
- Anakinra + Bcg vaccine live Contraindicated
- Anakinra + Measles mumps and rubella vaccine Contraindicated
- Anakinra + Measles mumps and rubella vaccine live Contraindicated
- Anakinra + Measles mumps rubella and varicella vaccine live Contraindicated
- Anakinra + Measles vaccine Contraindicated
- Abatacept + Anakinra Major
Other interactions of Tisagenlecleucel
Frequently asked questions
Can I take Anakinra with Tisagenlecleucel?
MediHelp rates the interaction as moderate. Anakinra and Tisagenlecleucel can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Anakinra is used off-label to manage CAR-T cytokine release syndrome and neurotoxicity, so the pairing is often intentional. The main concerns are added infection risk and a theoretical effect on CAR-T expansion and activity.
How serious is the interaction between Anakinra and Tisagenlecleucel?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use anakinra for CAR-T toxicity only under specialist oversight and monitor for infection and for response of the underlying malignancy.
What other medicines interact with Anakinra?
MediHelp also lists interactions of Anakinra with, for example, Bcg vaccine live, Measles mumps and rubella vaccine, Measles mumps and rubella vaccine live. The full list is on the Anakinra page.
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