Drug interactions
Anakinra + Trastuzumab
Severity: Moderate
Anakinra and Trastuzumab: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Anakinra increases infection susceptibility and trastuzumab can add to neutropenia when combined with myelosuppressive chemotherapy. The combination may raise infection risk in oncology patients.
What this interaction means in plain words
Anakinra and Trastuzumab can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Anakinra belongs to Musculoskeletal; Trastuzumab belongs to Oncology.
Why it happens
Additive effects on immune defense from IL-1 blockade and potential neutropenia in trastuzumab-chemotherapy regimens.
What to do
Monitor neutrophil counts and signs of infection. Hold anakinra if neutropenia or serious infection develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Anakinra
- Anakinra + Bcg vaccine live Contraindicated
- Anakinra + Measles mumps and rubella vaccine Contraindicated
- Anakinra + Measles mumps and rubella vaccine live Contraindicated
- Anakinra + Measles mumps rubella and varicella vaccine live Contraindicated
- Anakinra + Measles vaccine Contraindicated
- Abatacept + Anakinra Major
Other interactions of Trastuzumab
Frequently asked questions
Can I take Anakinra with Trastuzumab?
MediHelp rates the interaction as moderate. Anakinra and Trastuzumab can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Anakinra increases infection susceptibility and trastuzumab can add to neutropenia when combined with myelosuppressive chemotherapy. The combination may raise infection risk in oncology patients.
How serious is the interaction between Anakinra and Trastuzumab?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor neutrophil counts and signs of infection. Hold anakinra if neutropenia or serious infection develops.
What other medicines interact with Anakinra?
MediHelp also lists interactions of Anakinra with, for example, Bcg vaccine live, Measles mumps and rubella vaccine, Measles mumps and rubella vaccine live. The full list is on the Anakinra page.
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