Drug interactions
Androstenedione + Testosterone
Severity: Moderate
Androstenedione and Testosterone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Androstenedione is a precursor that is converted to testosterone and estrogens, so it adds to androgen exposure. Together they can increase androgenic adverse effects such as acne, hair growth, and erythrocytosis.
What this interaction means in plain words
Androstenedione and Testosterone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive androgenic effect through peripheral conversion of androstenedione to testosterone.
What to do
Avoid supplementary androstenedione during testosterone therapy and monitor testosterone levels and hematocrit.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Testosterone
- Testosterone + Warfarin Major
- Betamethasone + Testosterone Moderate
- Carbamazepine + Testosterone Moderate
- Corticotropin + Testosterone Moderate
- Cortisone + Testosterone Moderate
- Cyclosporine + Testosterone Moderate
Frequently asked questions
Can I take Androstenedione with Testosterone?
MediHelp rates the interaction as moderate. Androstenedione and Testosterone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Androstenedione is a precursor that is converted to testosterone and estrogens, so it adds to androgen exposure. Together they can increase androgenic adverse effects such as acne, hair growth, and erythrocytosis.
How serious is the interaction between Androstenedione and Testosterone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid supplementary androstenedione during testosterone therapy and monitor testosterone levels and hematocrit.
What other medicines interact with Testosterone?
MediHelp also lists interactions of Testosterone with, for example, Warfarin, Betamethasone, Carbamazepine. The full list is on the Testosterone page.
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