Drug interactions
Carbamazepine + Testosterone
Severity: Moderate
Carbamazepine and Testosterone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Carbamazepine, as an enzyme inducer, may lower testosterone exposure and efficacy. Testosterone's effect on carbamazepine is not well established, so toxicity is only theoretical.
What this interaction means in plain words
Carbamazepine and Testosterone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Carbamazepine belongs to Central Nervous System; Testosterone belongs to Endocrine.
Why it happens
Carbamazepine induces CYP3A4 and raises SHBG, reducing free testosterone; any effect of testosterone on carbamazepine metabolism is unproven.
What to do
Monitor serum testosterone and clinical response, and adjust the dose. Check carbamazepine levels if toxicity symptoms occur.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Carbamazepine and Testosterone, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Carbamazepine
- Artemether / lumefantrine + Carbamazepine Contraindicated
- Cabotegravir + Carbamazepine Contraindicated
- Carbamazepine + Delamanid Contraindicated
- Carbamazepine + Dienogest / estradiol valerate Contraindicated
- Carbamazepine + Doravirine Contraindicated
- Carbamazepine + Elbasvir / grazoprevir Contraindicated
Other interactions of Testosterone
- Testosterone + Warfarin Major
- Androstenedione + Testosterone Moderate
- Betamethasone + Testosterone Moderate
- Corticotropin + Testosterone Moderate
- Cortisone + Testosterone Moderate
- Cyclosporine + Testosterone Moderate
Frequently asked questions
Can I take Carbamazepine with Testosterone?
MediHelp rates the interaction as moderate. Carbamazepine and Testosterone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Carbamazepine, as an enzyme inducer, may lower testosterone exposure and efficacy. Testosterone's effect on carbamazepine is not well established, so toxicity is only theoretical.
How serious is the interaction between Carbamazepine and Testosterone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum testosterone and clinical response, and adjust the dose. Check carbamazepine levels if toxicity symptoms occur.
What other medicines interact with Carbamazepine?
MediHelp also lists interactions of Carbamazepine with, for example, Artemether / lumefantrine, Cabotegravir, Delamanid. The full list is on the Carbamazepine page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
