Drug interactions
Anthrax vaccine adsorbed + Procarbazine
Severity: Moderate
Anthrax vaccine adsorbed and Procarbazine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Procarbazine is a myelosuppressive, immunosuppressive chemotherapy that can blunt the antibody response to non-live vaccines, leaving patients incompletely protected.
What this interaction means in plain words
Anthrax vaccine adsorbed and Procarbazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Chemotherapy-induced immunosuppression reduces the immune response to vaccination.
What to do
Where feasible, vaccinate at least 2 weeks before starting procarbazine. Otherwise consider revaccination after immune recovery, at least 3 months after chemotherapy ends.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Procarbazine
- Adenovirus types 4 and 7 live + Procarbazine Contraindicated
- Amitriptyline + Procarbazine Contraindicated
- Amoxapine + Procarbazine Contraindicated
- Atomoxetine + Procarbazine Contraindicated
- Bcg vaccine live + Procarbazine Contraindicated
- Brimonidine + Procarbazine Contraindicated
Frequently asked questions
Can I take Anthrax vaccine adsorbed with Procarbazine?
MediHelp rates the interaction as moderate. Anthrax vaccine adsorbed and Procarbazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Procarbazine is a myelosuppressive, immunosuppressive chemotherapy that can blunt the antibody response to non-live vaccines, leaving patients incompletely protected.
How serious is the interaction between Anthrax vaccine adsorbed and Procarbazine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Where feasible, vaccinate at least 2 weeks before starting procarbazine. Otherwise consider revaccination after immune recovery, at least 3 months after chemotherapy ends.
What other medicines interact with Procarbazine?
MediHelp also lists interactions of Procarbazine with, for example, Adenovirus types 4 and 7 live, Amitriptyline, Amoxapine. The full list is on the Procarbazine page.
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