Drug interactions
Anthrax vaccine + Prednisone
Severity: Moderate
Anthrax vaccine and Prednisone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Corticosteroids suppress immune responses, so the antibody response to the anthrax vaccine may be weaker at immunosuppressive doses. The vaccine is not live, so there is no infection risk.
What this interaction means in plain words
Anthrax vaccine and Prednisone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Glucocorticoid-mediated immunosuppression blunting vaccine response.
What to do
Where possible give the vaccine before starting prednisone or when the dose is low. Vaccinate anyway when exposure risk is high and consider checking serological response.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Prednisone
- Bcg vaccine live + Prednisone Contraindicated
- Measles vaccine + Prednisone Contraindicated
- Mifepristone + Prednisone Contraindicated
- Prednisone + Radium-223 dichloride Contraindicated
- Prednisone + Smallpox vaccine live Contraindicated
- Adenovirus types 4 and 7 live + Prednisone Major
Frequently asked questions
Can I take Anthrax vaccine with Prednisone?
MediHelp rates the interaction as moderate. Anthrax vaccine and Prednisone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Corticosteroids suppress immune responses, so the antibody response to the anthrax vaccine may be weaker at immunosuppressive doses. The vaccine is not live, so there is no infection risk.
How serious is the interaction between Anthrax vaccine and Prednisone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Where possible give the vaccine before starting prednisone or when the dose is low. Vaccinate anyway when exposure risk is high and consider checking serological response.
What other medicines interact with Prednisone?
MediHelp also lists interactions of Prednisone with, for example, Bcg vaccine live, Measles vaccine, Mifepristone. The full list is on the Prednisone page.
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