Drug interactions
Prednisone + Radium-223 dichloride
Severity: Contraindicated
Prednisone and Radium-223 dichloride: contraindicated interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Prednisone is relevant here as the steroid given with abiraterone; that triple combination with radium-223 has shown more fractures and a mortality trend. Prednisone alone with radium-223 is not itself the identified concern.
What this interaction means in plain words
Prednisone and Radium-223 dichloride are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Prednisone belongs to Endocrine; Radium-223 dichloride belongs to Miscellaneous.
Why it happens
The mechanism is not established; additive bone toxicity has been proposed.
What to do
Avoid radium-223 in patients receiving abiraterone with prednisone. Review need for steroids and bone protection if used separately.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Other interactions of Radium-223 dichloride
- Abiraterone + Radium-223 dichloride Contraindicated
- Prednisolone + Radium-223 dichloride Contraindicated
- Radium-223 dichloride + Siponimod Moderate
- Calcium + Radium-223 dichloride Minor
- Radium-223 dichloride + Vitamin d Minor
Other interactions of Prednisone
- Bcg vaccine live + Prednisone Contraindicated
- Measles vaccine + Prednisone Contraindicated
- Mifepristone + Prednisone Contraindicated
- Prednisone + Smallpox vaccine live Contraindicated
- Adenovirus types 4 and 7 live + Prednisone Major
- Aldesleukin + Prednisone Major
Frequently asked questions
Can I take Prednisone with Radium-223 dichloride?
MediHelp rates the interaction as contraindicated. Prednisone and Radium-223 dichloride are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Prednisone is relevant here as the steroid given with abiraterone; that triple combination with radium-223 has shown more fractures and a mortality trend. Prednisone alone with radium-223 is not itself the identified concern.
How serious is the interaction between Prednisone and Radium-223 dichloride?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid radium-223 in patients receiving abiraterone with prednisone. Review need for steroids and bone protection if used separately.
What other medicines interact with Radium-223 dichloride?
MediHelp also lists interactions of Radium-223 dichloride with, for example, Abiraterone, Prednisolone, Siponimod. The full list is on the Radium-223 dichloride page.
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